“We are like children building a sand castle. We embellish it with beautiful shells, bits of driftwood, and pieces of colored glass. The castle is ours, off limits to others. We’re willing to attack if others threaten to hurt it. Yet despite all our attachment, we know that the tide will inevitably come in and sweep the sand castle away. The trick is to enjoy it fully but without clinging, and when the time comes, let it dissolve back into the sea.”— Pema Chödrön, When Things Fall Apart: Heart Advice for Difficult Times (via purplebuddhaproject)
“Letting there be room for not knowing is the most important thing of all. When there’s a big disappointment, we don’t know if that’s the end of the story. It may just be the beginning of a great adventure. Life is like that. We don’t know anything. We call something bad; we call it good. But really we just don’t know.”— Pema Chödrön, When Things Fall Apart: Heart Advice for Difficult Times (via purplebuddhaproject)
“People get into a heavy-duty sin and guilt trip, feeling that if things are going wrong, that means that they did something bad and they are being punished. That’s not the idea at all. The idea of karma is that you continually get the teachings that you need to open your heart. To the degree that you didn’t understand in the past how to stop protecting your soft spot, how to stop armoring your heart, you’re given this gift of teachings in the form of your life, to give you everything you need to open further.”—Pema Chödrön (via yeshecholwa)
“I no longer believed in the idea of soul mates, or love at first sight. But I was beginning to believe that a very few times in your life, if you were lucky, you might meet someone who was exactly right for you. Not because he was perfect, or because you were, but because your combined flaws were arranged in a way that allowed two separate beings to hinge together.”—Lisa Kleypas, Blue-Eyed Devil (via purplebuddhaproject)
Researchers at the University of California, San Diego School of Medicine have launched a phase 1 human clinical trial to assess the safety and efficacy of a new monoclonal antibody for patients with chronic lymphocytic leukemia (CLL), the most common form of blood cancer in adults.
The new antibody targets ROR1, a protein used by embryonic cells during early development and exploited by cancer cells to promote tumor growth and metastasis, the latter responsible for 90 percent of all cancer-related deaths.
Because ROR1 is not expressed by normal adult cells, scientists believe it is a biomarker of cancer cells in general and cancer stem cells in particular. Because it appears to drive tumor growth and disease spread, they believe it also presents an excellent target for anti-cancer therapy.
Developed at UC San Diego Moores Cancer Center by Thomas Kipps, MD, PhD, who holds the Evelyn and Edwin Tasch Chair in Cancer Research, and colleagues, the antibody is called cirmtuzumab (also known as UC-961). In previous animal studies, Kipps’ team reported that ROR1 is singularly expressed on CLL and also on a variety of different cancers, including cancers of the breast, pancreas, colon, lung and ovary. In mouse models of CLL, ROR1 acts as an accelerant when combined with another oncogene to produce a faster-growing, more aggressive cancer.
Cirmtuzumab was developed under the auspices of the California Institute for Regenerative Medicine’s HALT leukemia grant awarded to Dennis Carson, MD, principal investigator, and Catriona Jamieson, MD, PhD, co-principal investigator to develop six distinct therapies against cancer stem cells. Kipps led one of the six projects and generated antibodies against ROR1, leading to the cirmtuzumab trial in patients with CLL.
“The primary goal of this phase I clinical trial is to evaluate whether cirmtuzumab is a safe and well-tolerated cancer stem cell-targeted agent in patients with CLL,” said Jamieson, chief of the Division of Regenerative Medicine, associate professor of medicine, director of stem cell research at UC San Diego Moores Cancer Center, deputy director of the Sanford Stem Cell Clinical Center and a principal investigator of the cirmtuzumab clinical trial.
Michael Choi, MD, assistant clinical professor of medicine and co-principal investigator of the clinical trial said, “The trial will involve patients with relapsed or refractory CLL, who will receive an intravenous infusion every 14 days at Moores, followed by regular monitoring and clinic visits to assess efficacy and identify and manage any adverse effects. Initial treatment is planned for two months.”
To learn more about eligibility for this clinical trial, call Reilly L. Kidwell at 858-534-4801 or Samuel Zhang at 858-534-8127.
“With the outsourcing of most traditional manufacturing jobs and the rise of the service economy, in which most people who work stare into a screen all day — whether they work at Target or on Wall Street — has come a set of cultural shifts Scott does not mention. Work and entertainment exist on a continuum with no clear dividing line between the two, and the distinction between producer and consumer has become confused. Indeed, an individual citizen’s most important economic role, in the post-industrial West, is that of a consumer, inhaling goods, products, services and entertainment, as much of that as possible delivered electronically or shipped to your door. (Consumption power has grown even as real income has fallen and inequality has grown, one of the many paradoxes in late capitalism.) Being a producer in the old-fashioned sense comes second if it comes at all. Many of us — myself and A.O. Scott very much included — produce things that aren’t even things, and whose exchange-value and social utility are nebulous at best.”—The “death of adulthood” is really just capitalism at work (via azspot)
“We think that the point is to pass the test or overcome the problem, but the truth is that things don’t really get solved. They come together and they fall apart. Then they come together again and fall apart again. It’s just like that. The healing comes from letting there be room for all of this to happen: room for grief, for relief, for misery, for joy.”— Pema Chödrön (via purplebuddhaproject)
“It says in the brochure,” said Arthur, pulling it out of his pocket and lookingat it again, “that I can have a special prayer, individually tailored to me and my special needs.”
“Oh, all right,” said the old man. “Here’s a prayer for you. Got a pencil?”
“Yes,” said Arthur.
“It goes like this. Let’s see now: “Protect me from knowing what I don’t need to know. Protect me from even knowing that there are things to know that I don’t know. Protect me from knowing that I decided not to know about the things that I decided not to know about. Amen.”’ That’s it. It’s what you pray silently inside yourself anyway, so you may as well have it out in the open.”
“Hmmm,” said Arthur. Well, thank you -“
“There’s another prayer that goes with it that’s very important,” continued the old man, “so you’d better jot this down, too.”
“It goes, “Lord, lord, lord…”’ It’s best to put that bit in, just in case. You can never be too sure “Lord, lord, lord. Protect me from the consequences of the above prayer. Amen…” And that’s it. Most of the trouble people get into in life comes from missing out that last part.”
“A former LAPD officer turned sociologist (Cooper 1991) observed that the overwhelming majority of those beaten by police turn out not to be guilty of any crime. “Cops don’t beat up burglars”, he observed. The reason, he explained, is simple: the one thing most guaranteed to evoke a violent reaction from police is to challenge their right to “define the situation.” If what I’ve been saying is true this is just what we’d expect. The police truncheon is precisely the point where the state’s bureaucratic imperative for imposing simple administrative schema, and its monopoly of coercive force, come together. It only makes sense then that bureaucratic violence should consist first and foremost of attacks on those who insist on alternative schemas or interpretations. At the same time, if one accepts Piaget’s famous definition of mature intelligence as the ability to coordinate between multiple perspectives (or possible perspectives) one can see, here, precisely how bureaucratic power, at the moment it turns to violence, becomes literally a form of infantile stupidity.”—David Graeber, "Beyond Power/Knowledge: an exploration of the relation of power, ignorance and stupidity" - Malinowski Memorial Lecture at the London School of Economics (May 2006)
It appears that yesterday was my one good day this week, as today I am again exhausted. It was fun while it lasted! But, hey, I’m neither depressed nor anxious, for a change, so I’ll take it! If/when Orion goes over to his mom’s at noon, there may be a nap in my future.
How’s your Saturday, everybody? What are you up to?
We had a lot of trouble with western mental health workers who came here immediately after the genocide and we had to ask some of them to leave.
They came and their practice did not involve being outside in the sun where you begin to feel better. There was no music or drumming to get your blood flowing again. There was no sense that everyone had taken the day off so that the entire community could come together to try to lift you up and bring you back to joy. There was no acknowledgement of the depression as something invasive and external that could actually be cast out again.
Instead they would take people one at a time into these dingy little rooms and have them sit around for an hour or so and talk about bad things that had happened to them. We had to ask them to leave.
~A Rwandan talking to a western writer, Andrew Solomon, about his experience with western mental health and depression.
From The Moth podcast, ‘Notes on an Exorcism’. (via jacobwren)